Browsing by Author "de Halleux, Virginie"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    A Partly Fermented Infant Formula with Postbiotics Including 30 -GL, Specific Oligosaccharides, 20 -FL, and Milk Fat Supports Adequate Growth, Is Safe and Well-Tolerated in Healthy Term Infants: A Double-Blind, Randomised, Controlled, Multi-Country Trial
    (Nutrients, 2020) Vandenplas, Yvan; de Halleux, Virginie; Arciszewska, Małgorzata; Lach, Piotr; Pokhylko, Valeriy; Klymenko, Viktoriia; Schoen, Stefanie; Abrahamse-Berkeveld, Marieke; Kelly, A Mulder; Rocio, Porcel Rubio
    This study investigated growth, safety, and tolerance in healthy infants consuming a partly fermented infant formula (IF) with postbiotics, 20-linked fucosyllactose (20-FL), a specific prebiotic mixture of short-chain galacto-oligosaccharides (scGOS) and long-chain fructo-oligosaccharides (lcFOS), and milk fat. This double-blind, controlled trial randomised 215 fully IF-fed infants ≤14 days of age to either: Test Group (IF) containing 26% fermented formula with postbiotics derived from Lactofidus fermentation process (including 30 -Galactosyllactose; 30 -GL), 0.8 g/100 mL scGOS/lcFOS (9:1), 0.1 g/100 mL 20 -FL, and milk fat), or Control group (IF with 0.8 g/100 mL scGOS/lcFOS (9:1)) until 17 weeks of age. Fully breastfed infants were included as a reference. Anthropometric measures, gastrointestinal symptoms, and safety were assessed monthly. Equivalence in weight gain (primary outcome) between the Test and Control groups was confirmed (difference in means −0.08 g/d; 90% CI (−1.47;1.31)) with estimated mean weight gain (SE) of 31.00 (0.59) g/d and 31.08 (0.60) g/d, respectively, (PP population, n = 196). Equivalence in length and head circumference gain between the randomised groups was also confirmed. No statistically significant differences were observed in adverse events or gastrointestinal tolerance between randomised IF groups. A partly fermented IF with postbiotics, specific oligosaccharides, 20 -FL, and milk fat supports adequate infant growth and is safe and well-tolerated in healthy term infants.