{\rtf1\adeflang1037\ansi\ansicpg1251\uc1\adeff0\deff41\stshfdbch0\stshfloch41\stshfhich41\stshfbi41\deflang1049\deflangfe2052{\fonttbl{\f0\froman\fcharset204\fprq2{\*\panose 02020603050405020304}Times New Roman;}{\f1\fswiss\fcharset204\fprq2{\*\panose 020b0604020202020204}Arial;}
{\f41\fswiss\fcharset204\fprq2{\*\panose 020f0502020204030204}Calibri;}{\f306\froman\fcharset0\fprq2 Times New Roman;}{\f304\froman\fcharset238\fprq2 Times New Roman CE;}{\f307\froman\fcharset161\fprq2 Times New Roman Greek;}
{\f308\froman\fcharset162\fprq2 Times New Roman Tur;}{\f309\fbidi \froman\fcharset177\fprq2 Times New Roman (Hebrew);}{\f310\fbidi \froman\fcharset178\fprq2 Times New Roman (Arabic);}{\f311\froman\fcharset186\fprq2 Times New Roman Baltic;}
{\f312\froman\fcharset163\fprq2 Times New Roman (Vietnamese);}{\f316\fswiss\fcharset0\fprq2 Arial;}{\f314\fswiss\fcharset238\fprq2 Arial CE;}{\f317\fswiss\fcharset161\fprq2 Arial Greek;}{\f318\fswiss\fcharset162\fprq2 Arial Tur;}
{\f319\fbidi \fswiss\fcharset177\fprq2 Arial (Hebrew);}{\f320\fbidi \fswiss\fcharset178\fprq2 Arial (Arabic);}{\f321\fswiss\fcharset186\fprq2 Arial Baltic;}{\f322\fswiss\fcharset163\fprq2 Arial (Vietnamese);}{\f716\fswiss\fcharset0\fprq2 Calibri;}
{\f714\fswiss\fcharset238\fprq2 Calibri CE;}{\f717\fswiss\fcharset161\fprq2 Calibri Greek;}{\f718\fswiss\fcharset162\fprq2 Calibri Tur;}{\f721\fswiss\fcharset186\fprq2 Calibri Baltic;}{\f722\fswiss\fcharset163\fprq2 Calibri (Vietnamese);}}
{\colortbl;\red0\green0\blue0;\red0\green0\blue255;\red0\green255\blue255;\red0\green255\blue0;\red255\green0\blue255;\red255\green0\blue0;\red255\green255\blue0;\red255\green255\blue255;\red0\green0\blue128;\red0\green128\blue128;\red0\green128\blue0;
\red128\green0\blue128;\red128\green0\blue0;\red128\green128\blue0;\red128\green128\blue128;\red192\green192\blue192;}{\stylesheet{\ql \li0\ri0\sa200\sl276\slmult1\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 
\af0\afs22\alang1025 \ltrch\fcs0 \f41\fs22\lang1049\langfe1049\cgrid\langnp1049\langfenp1049 \snext0 Normal;}{\*\cs10 \additive \ssemihidden Default Paragraph Font;}{\*
\ts11\tsrowd\trftsWidthB3\trpaddl108\trpaddr108\trpaddfl3\trpaddft3\trpaddfb3\trpaddfr3\trcbpat1\trcfpat1\tscellwidthfts0\tsvertalt\tsbrdrt\tsbrdrl\tsbrdrb\tsbrdrr\tsbrdrdgl\tsbrdrdgr\tsbrdrh\tsbrdrv 
\ql \li0\ri0\widctlpar\aspalpha\aspnum\faauto\adjustright\rin0\lin0\itap0 \rtlch\fcs1 \af41\afs20 \ltrch\fcs0 \f41\fs20\lang1024\langfe1024\cgrid\langnp1024\langfenp1024 \snext11 \ssemihidden Normal Table;}{
\s15\ql \li0\ri0\nowidctlpar\faauto\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1081 \ltrch\fcs0 \f41\fs24\lang1049\langfe2052\kerning1\cgrid\langnp1049\langfenp2052 \snext15 \'c1c1\'e0e0\'e7e7\'eeee\'e2e2\'fbfb\'e9e9;}{
\s16\ql \li0\ri0\sb240\sa120\keepn\nowidctlpar\faauto\rin0\lin0\itap0 \rtlch\fcs1 \af1\afs28\alang1025 \ltrch\fcs0 \fs28\lang1049\langfe1049\loch\f1\hich\af0\dbch\af0\cgrid\langnp1049\langfenp1049 \sbasedon15 \snext17 
\'c7c7\'e0e0\'e3e3\'eeee\'ebeb\'eeee\'e2e2\'eeee\'eaea;}{\s17\ql \li0\ri0\sa120\nowidctlpar\faauto\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \f41\fs24\lang1049\langfe1049\cgrid\langnp1049\langfenp1049 \sbasedon15 \snext17 
\'cece\'f1f1\'eded\'eeee\'e2e2\'eded\'eeee\'e9e9 \'f2f2\'e5e5\'eaea\'f1f1\'f2f2;}{\s18\ql \li0\ri0\sa120\nowidctlpar\faauto\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \f41\fs24\lang1049\langfe1049\cgrid\langnp1049\langfenp1049 
\sbasedon17 \snext18 \'d1d1\'efef\'e8e8\'f1f1\'eeee\'eaea;}{\s19\ql \li0\ri0\sb120\sa120\nowidctlpar\noline\faauto\rin0\lin0\itap0 \rtlch\fcs1 \ai\af0\afs24\alang1025 \ltrch\fcs0 \i\f41\fs24\lang1049\langfe1049\cgrid\langnp1049\langfenp1049 
\sbasedon15 \snext19 \'cdcd\'e0e0\'e7e7\'e2e2\'e0e0\'eded\'e8e8\'e5e5;}{\s20\ql \li0\ri0\nowidctlpar\noline\faauto\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \f41\fs24\lang1049\langfe1049\cgrid\langnp1049\langfenp1049 
\sbasedon15 \snext20 \'d3d3\'eaea\'e0e0\'e7e7\'e0e0\'f2f2\'e5e5\'ebeb\'fcfc;}}
{\*\latentstyles\lsdstimax156\lsdlockeddef0{\lsdlockedexcept Normal;heading 1;heading 2;heading 3;heading 4;heading 5;heading 6;heading 7;heading 8;heading 9;toc 1;toc 2;toc 3;toc 4;toc 5;toc 6;toc 7;toc 8;toc 9;caption;Title;Default Paragraph Font;Subtitle;Strong;Emphasis;Table Grid;}}
{\*\rsidtbl \rsid19506\rsid27788\rsid94375\rsid226090\rsid463977\rsid555472\rsid612121\rsid727726\rsid787804\rsid808075\rsid1250169\rsid1376347\rsid1442029\rsid1461933\rsid1529816\rsid1586957\rsid1591737\rsid1902350\rsid2105311\rsid2125210\rsid2303848
\rsid2504678\rsid2587251\rsid2708713\rsid2838471\rsid2885731\rsid2965696\rsid3091741\rsid3095458\rsid3150730\rsid3174395\rsid3242096\rsid3304558\rsid3347230\rsid3358986\rsid3474375\rsid3480953\rsid3543648\rsid3701250\rsid3832818\rsid3946056\rsid4217065
\rsid4669864\rsid4749872\rsid5047706\rsid5139827\rsid5203239\rsid5244685\rsid5335877\rsid5394291\rsid5590229\rsid5644280\rsid5667045\rsid5731336\rsid5964785\rsid6381890\rsid6424218\rsid6897246\rsid7015982\rsid7026909\rsid7363487\rsid7698781\rsid7749279
\rsid7808768\rsid7809644\rsid7830661\rsid7890251\rsid7999763\rsid8018165\rsid8021590\rsid8128504\rsid8198189\rsid8591637\rsid8602896\rsid8604050\rsid8660549\rsid8661322\rsid8662933\rsid8676891\rsid8983980\rsid9011135\rsid9061309\rsid9066238\rsid9248872
\rsid9253289\rsid9324161\rsid9386075\rsid10373074\rsid10384090\rsid10385616\rsid10443280\rsid10445247\rsid10707616\rsid10906070\rsid11038514\rsid11104066\rsid11277580\rsid11501225\rsid11626412\rsid11632306\rsid11674419\rsid11678181\rsid11864818
\rsid11957840\rsid12134330\rsid12405235\rsid12418894\rsid12525514\rsid12541474\rsid12605899\rsid13003238\rsid13005366\rsid13520163\rsid13721484\rsid13787124\rsid14094613\rsid14251479\rsid14352964\rsid14425252\rsid14639249\rsid14680916\rsid14756976
\rsid14812008\rsid14814471\rsid15354488\rsid15495685\rsid15539757\rsid15546187\rsid15612371\rsid15667154\rsid15929566\rsid15934542\rsid15950951\rsid16406998\rsid16533457\rsid16595895\rsid16609455\rsid16657647\rsid16672826}{\*\generator Microsoft Word 11.
0.5604;}{\info{\author User}{\operator User}{\creatim\yr2014\mo2\dy10\hr11\min11}{\revtim\yr2017\mo12\dy14\hr10\min3}{\printim\yr2014\mo2\dy10\hr11\min4}{\version131}{\edmins928}{\nofpages1}{\nofwords310}{\nofchars1772}{\nofcharsws2078}{\vern24689}}
\paperw11906\paperh16838\margl1134\margr1134\margt661\margb564\ltrsect \deftab709\widowctrl\ftnbj\aenddoc\hyphhotz425\noxlattoyen\expshrtn\noultrlspc\dntblnsbdb\nospaceforul\hyphcaps0\formshade\horzdoc\dghspace120\dgvspace120\dghorigin1701\dgvorigin1984
\dghshow0\dgvshow3\jcompress\viewkind1\viewscale89\nolnhtadjtbl\rsidroot10384090 \fet0\ltrpar \sectd \ltrsect\sbknone\linex0\headery708\footery708\sectunlocked1\sectdefaultcl\sftnbj {\*\pnseclvl1\pnucrm\pnstart1\pnindent720\pnhang {\pntxta .}}
{\*\pnseclvl2\pnucltr\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl3\pndec\pnstart1\pnindent720\pnhang {\pntxta .}}{\*\pnseclvl4\pnlcltr\pnstart1\pnindent720\pnhang {\pntxta )}}{\*\pnseclvl5\pndec\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}
{\*\pnseclvl6\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl7\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl8\pnlcltr\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}{\*\pnseclvl9
\pnlcrm\pnstart1\pnindent720\pnhang {\pntxtb (}{\pntxta )}}\pard\plain \ltrpar\s17\ql \li0\ri0\sa120\nowidctlpar\faauto\rin0\lin0\itap0 \rtlch\fcs1 \af0\afs24\alang1025 \ltrch\fcs0 \f41\fs24\lang1049\langfe1049\cgrid\langnp1049\langfenp1049 {\rtlch\fcs1 
\af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11501225 
\par }\pard \ltrpar\s17\qj \li0\ri0\sa120\nowidctlpar\faauto\rin0\lin0\itap0\pararsid2838471 {\rtlch\fcs1 \ab\af0\afs28 \ltrch\fcs0 \b\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid2838471\charrsid8660549 A rare disease of the mitochondria}{\rtlch\fcs1 
\ab\af0\afs28 \ltrch\fcs0 \b\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid5644280\charrsid8660549 l respiratory chain}{\rtlch\fcs1 \ab\af0\afs28 \ltrch\fcs0 \b\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid2838471\charrsid8660549  \endash 
 3-methylglutaconic aciduria. Approach to diagnosis and rehabilitation}{\rtlch\fcs1 \ab\af0\afs28 \ltrch\fcs0 \b\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid10707616\charrsid8660549 
\par }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11501225 O}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid5244685  Grechanina, }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11501225 Y}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid2708713  Grechanina}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11501225 , S Biletska, I Maksyutina}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid2708713  }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\cf1\lang1033\langfe1049\super\langnp1033\insrsid11678181\charrsid5244685 
\par }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid3304558\charrsid3304558 Kharkiv Interregional Specialized Medical Genetic Centre \endash  Centre of Rare (Orphan) Diseases}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid1902350 , }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid3304558 Kharkiv}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid1902350 , Ukraine}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid3304558 
\par }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid7363487\charrsid7363487 Kharkiv Research Institute of Medical Genetic of Kharkiv National Medical University, Ukraine}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid7363487\charrsid11501225 
\par }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11678181\charrsid13005366 Introduction}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11678181\charrsid7808768 :}{\rtlch\fcs1 
\af0\afs28 \ltrch\fcs0 \b\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid10906070\charrsid7808768  }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid7808768  }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid5644280\charrsid5644280 
Hereditary diseases of the mitochondrial respiratory chain are detected late, do not have etiological treatment. The existence of methods for correcting oxidative phosphorylation is }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid7808768 a motivation for early diagnostics}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid5644280\charrsid5644280 .}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid94375\charrsid14756976 
\par }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid14756976 Purpose}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid14756976\charrsid14756976 : 
To study the clinical phenotype of a rare disease, to evaluate the effect of synthropy on the clinical and biochemical features of the pathology for developing a strategy for improving the quality of life of patients.
\par }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11678181\charrsid13005366 Description}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11678181\charrsid11038514 :}{\rtlch\fcs1 
\af0\afs28 \ltrch\fcs0 \b\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11678181\charrsid11038514  }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 Since 2014, 7997 patients
 with suspected hereditary metabolic diseases have}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455  undergone gas chromatography/}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 mass spectrometry}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455  of urine. An increase of}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455  the level of 3-methylglutaconic acid was found in 1,070 cases. In 2 patients, its level }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid2504678 
remained elevated and coincided. }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 Monitoring for the family lasts 5 years. Both patients are siblings 3 an}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455 d 5 years old. Sick from birth - psycho-motor retardation, muscle hypotonia}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 
, pyramidal insufficiency, mic}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455 rocephaly, epilepsy}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 
. Excluded are the Rett and Angelmann syndrome. }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455 At the examination - }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 nonspecific hyp}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455 eraminoacidopathy}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1058\langfe1049\langnp1058\insrsid16609455 , }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455 lactate-acidosis}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid2504678 , }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid3174395 hiperhomocysteinemia, }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 MT}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid8604050 H}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 FR 677 }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid8604050 C/T, MTRR 66 G/}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 G (violat}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid8604050 ion of cobalamin E)}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 . The treatment strategy is aimed at long-term correction of the revealed disorders in the form of }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid8604050 a combination of energotropic}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid16609455 
 and folate therapy, complex rehabilitation with the use of special nutrition (USA) and correction of natural nutrition in accordance with biochemical indicators. The quality of life of patients is progressively improving.}{\rtlch\fcs1 \af0\afs28 
\ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid16609455\charrsid11038514 
\par }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11678181\charrsid13005366 Conclusions}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11678181\charrsid16609455 :}{\rtlch\fcs1 
\af0\afs28 \ltrch\fcs0 \b\f0\fs28\cf1\lang1033\langfe1049\langnp1033\insrsid11678181\charrsid16609455  }{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 \f0\fs28\lang1033\langfe1049\langnp1033\insrsid11038514\charrsid11038514 Diseases of the resp
iratory chain of mitochondria are many-sided, rare, in total constitute a great medical and social problem and are subject to individual etiopathogenetic and symptomatic therapy.}{\rtlch\fcs1 \af0\afs28 \ltrch\fcs0 
\f0\fs28\lang1033\langfe1049\langnp1033\insrsid11038514\charrsid16609455 
\par }}