THREE STEPS TO STUDY COMORBIDITY OF PSORIASIS AND CARDIOVASCULAR DISORDERS
BILOVOL A.N., TKACHENKO S.G.
Kharkiv national medical university, Kharkiv, Ukraine
The study of such psoriasis comorbidities as cardiometabolic disorders  (CMD), their relationship and interdependence is one of the most promising tasks of modern dermatology.
First step. The markers of metabolic syndrome (MS) of the National Cholesterol Education Programme in the U.S. criteria (NCEP ATP III, 2001.) and the International Diabetes Federation criteria (IDF, 2005) were investigated in 58 patients with psoriasis  aging from 19 to 86 years old (52 men and 6 women) were examined. Comorbidity of psoriasis and MS according to the NCEP ATP III, 2001 was diagnosed in 14 (24 %) cases, according to the IDF 2005 criteria in 24 (41 %) cases.
Second step. We have studied indicators of CMD in 205 psoriatic patients 19-80 y.o, 56 female - 27, 3 % and149 male - 72, 7 %. Elevated BMI was recorded in 103 (50, 2 %) patients, with an increased risk of CMD in 79 (38, 5 %) patients, moderate risk- in 20 (9, 8 %) and significant risk- in 4 (1, 9 %). Abdominal obesity was detected in 109 patients (53.1%). Arterial hypertension was detected in 93 patients (53%). Hyperglycemia was detected in 33 patients (19%). The most prevalence of cardiometabolic disorders was in the age group of 40-60 years.
Third step. A total of 230 patients with psoriasis (122 men -53% and 108 women -47%) were examined in the age range of 40-65 years, an average of 52.7 ± 1.3 y.o. The arterial hypertension (AH) was observed in 48 (20, 8 %) patients. Depending of the level of blood pressure patients were distributed as follows: mild hypertension (I degree) was diagnosed in 18 patients (37.5 %), moderate AH (Ⅱ degree) was observed in 30 patients (62.5 %). Results of electrocardiographic studies showed also signs of syndrome of early repolarization of ventricle in 32 patients (67 %), including 14 (29 %) men and 18 (37.5 %) women.

Ткаченко Светлана Геннадиевна
Кафедра дерматологии, венерологии и медицинской косметологии
Харьковского национального медицинского университета
61002, г. Харьков, Куликовский спуск,15 
е-mail: tkachenkosve@gmail.com
+380671223703