Syed Mujheed Abbas, Ashcheulova Tetiana 
BIOMARKERS OF INFLAMMATION PLASMA LEVELS IN PATIENTS WITH ARTERIAL HYPERTENSION DEPEND ON ABDOMINAL OBESITY PRESENCE
Propedeutics to Internal Medicine Department N1, Basis of Bioethics and Biosafety
Supervisor: Doctor of Medical Science, Professor O.M. Kovalyova
Kharkiv National Medical University
Kharkiv, Ukraine
	
Objective. Abdominal obesity (AO) is one of the most frequent associated to arterial hypertension (AH) condition that closely related to cytokines activation.  Interleukin-18 (IL-18) levels have been detected to be elevated in patients with metabolic syndrome. It was found association of interleukin-10 (IL-10) levels with obesity, metabolic syndrome and insulin content.  
The aim of our study was to investigate plasma proinflammatory cytokine – IL-18 and anti-inflammatory cytokine – IL-10 levels depend on AO presence in patients with AH. 
Design and Methods. 104 hypertensives were examined. Plasma IL-18 and IL-10 levels by ELISA were measured. Patients were divided into groups depend on AO presence: 1st group: 32 pts (30.8 %) without AO, 2nd group: 72 (69.2 %) pts with AO associated AH.
Results. AO presence in patients with AH was associated with elevation of circulating plasma IL-18 levels (175.2 ± 2.6 pg/ml) as compared with AH without AO (169.2 ± 4.0 pg/ml; p <0.05). 
There were no statistically significant difference in plasma IL-10 means in patients of 1st group (85.9 ±1.4 pg/ml) and 2nd group (85.5 ±0.8 pg/ml; p > 0.05) in our clinical study of patients with AH.
Correlation analysis shown significant relationships between plasma IL-18 levels and waist circumference mean in hypertensive patients with abdominal type of body fat distribution (r=0.39; p<0.05). Insignificant correlations were found between IL-10 and waist circumference in AH associated with AO.
Conclusions. Obtained results suggest that AO is accompanied by elevation of immune inflammatory activation in patients with AH.