Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/818
Title: | Isomeric 3-isoxadiazolylcoumarins and their derivatives |
Authors: | Detistov, Oleksandr Orlov, V. Zhuravel`, I. |
Keywords: | 1,2,4-oxadiazole coumarins synthetic ways |
Issue Date: | 2012 |
Publisher: | Wiley |
Citation: | Detistov O. S. Іsomeric 3-isoxadiazolylcoumarins and their derivatives / O. S. Detistov, V. D. Orlov, I. O. Zhuravel` // J. Heterocyclic Chem. – 2012. – Vol. 49. – P. 883–892. |
Abstract: | Here we represent preparative methods of synthesis of isomeric 3-isoxadiazolylcoumarins and their derivatives. Two new synthetic methods have been developed for 3-[1,2,4-oxadiazol-5-yl]coumarins I. The first method is based on a three-component condensation of coumarin-3-carboxylic acids, CDI and amidoximes. The second method essentially uses the interaction of 5-cyanomethyl-1,2,4-oxadiazoles with salicylic aldehydes. General approach for preparation of 3-[1,2,4-oxadiazol-3-yl]coumarins II has been worked out. Moreover, above mentioned synthetic ways open the way for the synthesis of 2-iminoderivatives III and IV not described before, those were diversified by reaction of nucliophilic substitution of 2-imino group with a numerous amino compounds. |
URI: | https://repo.knmu.edu.ua/handle/123456789/818 |
ISSN: | 0022-152X |
Appears in Collections: | Наукові праці. Кафедра медичної та біоорганічної хімії |
Files in This Item:
File | Description | Size | Format | |
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jhet893_published_d.pdf | 8,32 MB | Adobe PDF | View/Open |
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