Features of the lipid metabolism in patients with hypertension and overweight

Abstract

The recent interest in lipid metabolism in hypertension increased significantly, due to a focus on the pathophysiology of fat metabolism in obesity, diabetes and related conditions such as hypertension. So, the aim of this study was to identify the characteristics of lipid and carbohydrate metabolism in hypertensive patients combined with overweight. The study involved 55 hypertension patients. There were examined 19 people in control group with normal blood pressure, no carbohydrate metabolism disorders, and other chronic comorbidities. Fasting insulin concentrations in serum were determined by ELISA. Fasting glucose was performed by glucose oxidase method. The level of total cholesterol, triglycerides, high-density lipoprotein, low density lipoprotein cholesterol was determined in serum by photocolorimetric method. The hypertensive patients compared with the control group have got higher levels of systolic and diastolic blood pressure. In addition, the body mass index, hips, waist ratio, levels of total cholesterol, very low density lipoprotein cholesterol, triglycerides and index of atherogenic were elevated in patients with hypertension, which was accompanied by an increase in overweight. Consequently, the lipid metabolism disorders in hypertensive patients were earlier than the metabolic abnormalities of glucose and accompanied with overweight