Мінеральні предиктори формування патології шлунково-кишкового тракту у дітей з недиференційованою дисплазією сполучної тканини

Abstract

У роботі представлені результати п’ятирічного моніторингу дітей з недиференційованою дисплазією сполучної тканини. Визначені мінеральні предиктори формування різних форм диспластикозалежної патології травної системи у дітей: збільшення рівню цинку (r=0,78) з одночасним накопиченням нікелю (r=0,80) та наявність виразного дисбалансу співвідношення калію та кальцію, щодо формування патології на тлі малих аномалії розвитку органів травної системи – підвищення стронцію, хрому, заліза (r=0,69) та виразного зниження калію, магнію, кальцію та цинку. В роботе представлены результаты пятилетнего мониторинга детей с недифференцированной дисплазией соединительной ткани. Определены минеральные предикторы формирования различных форм диспластикозависимой патологии пищеварительной системы у детей: увеличение уровня цинка (r=0,78) с одновременным накоплением никеля (r=0,80) и наличием выраженного дисбаланса соотношения калия и кальция; относительно формирования патологии на фоне малых аномалий развития органов пищеварительной системы – повышение стронция, хрома, железа (r=0,69) и выраженного снижения калия, магния, кальция и цинка. Chronic diseases of gastrointestinal tract (GIT) hold much significance as pertaining to children’s somatic pathology. The problem of chronic pathology of the GIT in children with syndrome of undifferentiated dysplasia of the connective tissue (UDCT) is of special significance, as fibrillogenesis disorders and minor development abnormalities (MDA) of the GIT organs lead to formation of a polysystem dysplastic dependent pathology (DDP) of the GIT. Furthermore, a significant percentage of pathological conditions of the child's organism result from imbalance of microelements (ME) in tissues, and this fact evidences urgency of this research. Purpose of research: Identifying mineral predictors of formation of chronic diseases of gastrointestinal tract in children with fibrillogenesis disorders. During 5 years, 350 children aged 10-15 years with the UDCT syndrome were under dynamic observation. Assessment of the mineral profile was based on the mass spectrometry method using ElvaX equipment with analysis of ME in hair. The children were divided into the following clinical groups: Group І consisted of 108 (30.9%) children with DDP of the digestive system with underlying fibrillogenesis disorders, among them 46 (42.6%) children had functional disorders of the GIT and 62 (57.4%) children with DDP of the digestive system with underlying MDA of the GIT. Group II consisted of 242 (69.1%) children with the UDCT: subgroup II-a - 138 (57%) children with dyspeptic complaints without verified DDP of the digestive system; subgroup ІІ-b - 104 (43%) children with MDA of the digestive system organs with no complaints or clinical signs of the disease. Analysis of the obtained results showed that in the children of group І the mineral profile was defined by actual increase in the level of Zn by 45% (р<0.005), Са by 67% (р<0.005), Ві by 72% (р<0.005), Аl by 74% (р<0.005), Вr by 74.5% (р<0.005), Рb by 53% (р<0.005) and by decrease in the level of Sе by 76% (р<0.005), Со by 60% (р<0.005), Мn by 65% (р<0.005), Fe by 62% (р<0.005) and Мg by 31% (р<0.005). In the children of this group with DDP of the digestive system with underlying MDA of the GTI, the mineral imbalance was caused by significant magnification of Рb by 72% (р<0.005), Сr by 59% (р<0.005), Аl by 55% (р<0.005), Sr by 33% (р<0.005) and Мо by 21% (р<0.005) and actual decrease in the level of Мn and Мg by 66% (р<0.005), Сu and Se by 53% (р<0.005), Sі by 55% (р<0.001), Zn and Fе by 54% (р<0.005), Са by 43% (р<0.005) and Вr by 15% (р<0.005). In the course of such 5-year monitoring, in 89% of the children of group ІІ-a the DDP of the GIT was diagnosed with typical changes as pertaining to the increase of Zn, Аl, Рb, Сu, as well as to the decrease of Мn (р<0.05). In 92% of the children of group ІІ-b, in this stage the GIT pathology was diagnosed, and the mineral imbalance was defined by significant increase in the level of Sr and decrease of essential ME – Мg, Сu and Fe (р<0.05). Summarizing the results of monitoring of the mineral composition of hair of the children with the UDCT, it can be stated that it is the gradual increase in the level of Zn (r=0.78), Аl (r=0.72), Рb (r=0.61), Сu (r=0.55) with simultaneous decrease of Мn (r=0.80) that can be recognized as mineral predictors of formation of the DDP of the GIT. Magnification of Sr (r=0.69) and decrease of Мg (r=0.81), Мn (r=0.54), Сu (r=0.66) and Fe (r=0.52) may be considered as mineral predictors of formation of this type of the DDP of the digestive system in the children with the UDCT.