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Наукові роботи молодих вчених. Кафедра внутрішньої медицини № 1 >

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Название: Hyperinterleukinemia, insulinresistance in hypertensive patients with prediabetes
Авторы: Kochubei, Oksana
Ключевые слова: Hyperinterleukinemia, insulinresistance, hypertension, prediabetes
Дата публикации: 16-Май-2013
Библиографическое описание: Kochubiei О. Hyperinterleukinemia, insulinresistance in hypertensive patients with prediabetes / О.А. Кочубєй // Внесок молодих вчених у розвиток медичної науки і практики: нові перспективи : матеріали науково-практичної конференції з міжнародною участю присвяченої Дню науки, Харків, 16 травня 2013 р. / ДУ Ін-т терапії ім. Л. Т. Малої НАМН України, Харк. нац. мед. ун-т та ін. – Х., 2013. – С. 28.
Аннотация: Interleukin-6 is pleiotropic cytokine with a key impact on immunoregulation and nonimmune events. Sudies have investigated the role of action/lack of action of Interleukin-6 in the pathogeneses obesity, insulin resistance, type 2 diabetes. Aim of the study: to evaluate interleukin-6 activity in hypertensive patients depend on prediabetes presence. Materials and methods: 73 hypertensive patients were examined. Common clinical investigations, were provided. Interleukin-6 plasma levels were detected using ELISA. Data is represented as Me (Q25-Q75). Median test were used, р <0,05. Results: Prediabetes was observed in 36,2% of hypertensive patients, in 71% insulinresistance in hypertensive patients with prediabetes vs 54 % insulinresistance in hypertensive patients were detected. Hypertensive patients with prediabetes (5,90 (5,20-7,10) %) characterized by significantly higher glycated haemoglobin levels as compared hypertensive patients (5,40 (4,70-6,97) %, р<0,05). Hypertensive patients were characterized by increased interleukin-6 activity (18,81 (13,14-26,69) pg/ml). In hypertensive patients with prediabetes decrease interleukin-6 activity (13,94 (11,00-16,94) pg/ml )were found. Conclusion: Hypertensive patients were characterized by increased interleukin-6 activity, in hypertensive patients with prediabetes decrease interleukin-6 activity were found, that can be explained by double effects of interleukin-6 family, representatives of which or can lead to insulinresistance development, or on the contrary can improve tissue insulinsensitivity. From other side, the possibility is not exclude that hypertension is a more strong incentive, which leads to hyperinterleukinemia in hypertensive patients.
Описание: Interleukin-6 is pleiotropic cytokine with a key impact on immunoregulation and nonimmune events. Sudies have investigated the role of action/lack of action of Interleukin-6 in the pathogeneses obesity, insulin resistance, type 2 diabetes. Aim of the study: to evaluate interleukin-6 activity in hypertensive patients depend on prediabetes presence. Materials and methods: 73 hypertensive patients were examined. Common clinical investigations, were provided. Interleukin-6 plasma levels were detected using ELISA. Data is represented as Me (Q25-Q75). Median test were used, р <0,05. Results: Prediabetes was observed in 36,2% of hypertensive patients, in 71% insulinresistance in hypertensive patients with prediabetes vs 54 % insulinresistance in hypertensive patients were detected. Hypertensive patients with prediabetes (5,90 (5,20-7,10) %) characterized by significantly higher glycated haemoglobin levels as compared hypertensive patients (5,40 (4,70-6,97) %, р<0,05). Hypertensive patients were characterized by increased interleukin-6 activity (18,81 (13,14-26,69) pg/ml). In hypertensive patients with prediabetes decrease interleukin-6 activity (13,94 (11,00-16,94) pg/ml )were found. Conclusion: Hypertensive patients were characterized by increased interleukin-6 activity, in hypertensive patients with prediabetes decrease interleukin-6 activity were found, that can be explained by double effects of interleukin-6 family, representatives of which or can lead to insulinresistance development, or on the contrary can improve tissue insulinsensitivity. From other side, the possibility is not exclude that hypertension is a more strong incentive, which leads to hyperinterleukinemia in hypertensive patients.
URI: http://repo.knmu.edu.ua/handle/123456789/3316
Располагается в коллекциях:Наукові роботи молодих вчених. Кафедра внутрішньої медицини № 1

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