Research of antiulcer activity of dietary concentrate of phenolic compounds of apples on models of experimental ulcer in rats

Abstract

Medicinal plants have been widely used in the treatment of many diseases, especially in the gastroenterology, given that the use of synthetic antiulcer drugs in clinical practice often leads to the development of various kinds of side effects and, accordingly, have a large list of contraindications. The aim of this experimental work was the study of the antiulcer activity of the food concentrate of phenolic compounds of apples on the models of experimental ulcers in rats. Materials and methods. The studies included two stages, which were carried out on models: stage I – a model of alco-hol–prednisolone stomach ulcer in rats, stage II – a model of indomethacin stomach ulcer in rats in accordance with the methodological recommendations of the SEC of the Ministry of Health of Ukraine. The studied concentrate was ad-ministered in a dose based on the total content of polyphenols – 9 mg per 100 g of weight. Quercetin at a dose of 5 mg/kg and ranitidine at a dose of 20 mg / kg were used as reference drugs. After replicating the models, a macroscop-ic examination of the gastric mucosa was carried out and the content of TBA-reactants and reduced glutathione in the stomach homogenate was determined. Results. Under pathological conditions, the therapeutic effect of the food concentrate of phenolic compounds of apples and reference drugs was comparable in terms of the degree of ulcer defect. It was proved that food concentrate of phe-nolic compounds of apples and reference drugs inhibit the course of lipid peroxidation reactions and support endoge-nous antioxidant defense systems. Conclusions. The obtained results make it possible to recommend a further study of the food concentrate of phenolic compounds of apples for the creation of a pharmaceutical preparation on its basis. A promising area of application of this concentrate will be the prevention and treatment of gastric ulcer.