Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/29075
Title: | Peculiarities of succinamide toxicokinetics as an antidiabetic agent upon single inhalaion exposure |
Authors: | Lalymenko, Olga Kudria, M. Zavgorodnii, Igor |
Keywords: | antidiabetic agent toxicokinetics chromatography |
Issue Date: | 2021 |
Publisher: | ЛНМУ імені Данила Галицького |
Citation: | Lalymenko O. Peculiarities of succinamide toxicokinetics as an antidiabetic agent upon single inhalaion exposure / O. Lalymenko, M. Kudria, I. Zavgorodnii // Актуальні проблеми профілактичної медицини : збірник наукових праць. – Львів, 2021. – Вип. 2 (22). – С. 133–138. |
Abstract: | The toxicokinetics of such antidiabetic agents, as fi-phenylethylamide of 2-oxysuccinanilic acid ф -PhEA-OSA) and its metabolites (2-hydroxyphenylsuccinamide (2-HPhSA) andfi-phenylethylsuccinamide ф-PhESA)) upon a single inhalation influence of fi-PhEA-OSA on the male rodents at the levels Limac та Limch has been studied. The quantification of studied substances in the blood plasma of male rats was conducted with the use of high-performance liquid chromatography (HPLC) followed by the spectrophotometric determination. The compounds were identified in blood plasma within 30 mins after the inhalation; the maximum plasma concentration of fi-PhESA was estimated to be higher than the concentration of fi-PhEA-OSAA and 2-HhHS. The compounds were shown to circulate for a long period in the blood stream; the 2-HPhS was counted to have the longest half-life in average; the biotransformation of в -PhEA-OSAA was calculated to be more intensive in comparison with its excretion. |
URI: | https://repo.knmu.edu.ua/handle/123456789/29075 |
Appears in Collections: | Наукові праці. Кафедра гігієни та екології № 2 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
PECULIARITIES OF SUCCINAMIDE TOXICOKINETICS.pdf | 287,74 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.