Changes of vitamins B1, B12 as predicting factors of peripheral polyneuropaty in pulmonary in tubercolosis patients

Abstract

Patients with newly diagnosed pulmonary tuberculosis (TB) had lower initial plasma levels of vi- tamins B1 and B12, compared to age- and sex-matched healthy persons. We did not find significant chang- es in vitamin B status and electroneuromyography during the treatment with combinations of isoniazid and first-line anti-TB drugs. During the treatment with combinations of linezolid and second-line anti-TB drugs, we identified significant decreases of plasma vi- tamin B1 and B12 levels and worsening of electroneu- romyography indices by sensory and motor fibers. The deficiency of vitamins B1 and B12 during treatment with linezolid can be considered as one of the pathogenetic mechanisms of progressive damage of peripheral nervous system in pulmonary tu- berculosis patients, which must be taken into account during the course of antitubercular therapy.