Please use this identifier to cite or link to this item:
http://repo.knmu.edu.ua/handle/123456789/24752
Title: | Effectiveness of Intravenous Isoniazid and Ethambutol Administration in Patients with Tuberculosis Meningoencephalitis and HIV Infection |
Authors: | Butov, Dmytro Feshchenko, Yurii Kuzhko, Mykhailo Gumeniuk, Mykola Yurko, Kateryna Grygorova, Alina Tkachenko, Anton Nekrasova, Natalia Tlustova, Tetiana Kikinchuk, Vasyl Peshenko, Alexandr Butova, Tetiana |
Keywords: | tuberculosis tuberculous meningitis Human immunodeficiency virus (HIV) treatment Isoniazid Ethambutol |
Issue Date: | 31-Aug-2019 |
Citation: | Effectiveness of Intravenous Isoniazid and Ethambutol Administration in Patients with Tuberculosis Meningoencephalitis and HIV Infection / D. Butov, Yu. Feshchenko, M. Kuzhko, M. Gumenuik, K. Yurko, A. Grygorova, A. Tkachenko, N. Nekrasova, T. Tlustova, V. Kikinchuk, A. Peshenko, T. Butova // Tuberculosis and Respiratory Diseases. – 2019. – № 4. – P. 1–8. |
Abstract: | Background. The aim of this study was to investigate the effectiveness of intravenous isoniazid (H) and ethambutol (E) administered in patients with new sputum positive drug-susceptible pulmonary tuberculosis (TB) with tuberculous meningoencephalitis (TM) and human immunodeficiency virus (HIV) co-infection in the intensive phase of treatment. Methods. Fifty-four patients with TB/TM and HIV co-infection were enrolled for this study. Group 1 comprised of 23 patients treated with E and H intravenously, while rifampicin and pyrazinamide were prescribed orally. Group 2 consisted of 31 patients treated with the first-line anti-TB drugs orally. The concentrations of H and E in blood serum were detected using a chromatographic method. Results. A significant improvement in the clinical symptoms and X-ray signs in patients treated intravenously with H and E was observed and compared to group 2. The sputum Mycobacterium tuberculosis positivity was observed during the second month of the treatment in 25.0% of patients from group 1 and 76.1% of the patients from the control group (p=0.003). In addition, nine patients (39.1%) died up to 6 months when H and E were prescribed intravenously compared with 22 (70.9%)in group 2 (p=0.023). Conclusion. In TB/TM with HIV, the intravenous H and E treatment was more effective than oral H and E treatment at 2 months of intensive treatment in sputum conversion as well as in clinical improvement, accompanied by significantly higher mean serum concentrations. In addition, the mortality rate was lower in intravenous H and E treatment compared to oral treatment. |
URI: | https://repo.knmu.edu.ua/handle/123456789/24752 |
Appears in Collections: | Наукові праці. Кафедра фтизіатрії та пульмонології |
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trd-82-e20.pdf | 253,48 kB | Adobe PDF | View/Open |
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