Experimental investigation of the influence of pharmaceutical composition on emotional behavioral reactions under conditions of formalin edema

Abstract

The analysis of the results of experimental studies of the effect of celecoxib, licopid and their pharmaceutical composition on the central nervous system by emotional-behavioral reactions in the test "open field" in the conditions of formalin edema indicates that the addition of licopid to celecoxib increased rat’s locomotor and orienting-research activities, the indicators of their emotional reactions (washings and urinations) in comparison with the mono-administration of celecoxib. The pharmaceutical composition of celecoxib and licopid is appropriate and promising for the study of anti-inflammatory and analgesic effects.