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DC Field | Value | Language |
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dc.contributor.author | Savelieva, E. | - |
dc.contributor.author | Vladimirova, I. | - |
dc.contributor.author | Kulikova, Oksana | - |
dc.contributor.author | Tishakova, T. | - |
dc.contributor.author | Butko, Yaroslava | - |
dc.date.accessioned | 2019-03-20T08:26:37Z | - |
dc.date.available | 2019-03-20T08:26:37Z | - |
dc.date.issued | 2019-01 | - |
dc.identifier.citation | The study of neuromediatory action of the combination drug “Memofit” under chronic immobilization stress / E. V. Savelieva, I. M. Vladimirova, O. V. Kulikova T. S. Tishakova, Ya. O. Butko // The bulletin the national academy of sciences of the republic of Kazakhstan. – 2019. – Vol. 1, № 377. – P. 6–13. | ru_RU |
dc.identifier.uri | https://repo.knmu.edu.ua/handle/123456789/22604 | - |
dc.description.abstract | Neuromediatory action of the combination drug “Memofit” has been studied using the parameters of lipid peroxidation products and antioxidant system. POL and antioxidant system were determined by marker indicators: specifically, the level of primary oxidation products – diene conjugates and secondary products – malonic dialdehyde; anti-oxidative systems; catalase activity and superoxide dismutase. Experimental research has been performed in 18 WAG rats with approximate body weight from 210 to 230 g. Stress-modeling action has been studied on the model of neuromuscular tension during 5, 15 and 30 days. Immobilization stress was modeled by keeping rats for 5 hours in plastic cages – plastic boxes. Blood serum was used for investigation. Level of primary oxidation products – diene conjugates (DC) and secondary products – malonic dialdehyde (MDA) and state of antioxidant system has been determined by spectrophotometric method. Based on the POL level parameters, we can make a conclusion, that the tested combination drug “Memofit” decreases TBA-AP and DC parameters only on the 30-th day statistically significant in relation to immobilization stress and reaches to control. The level of catalase at immobilization stress + combination drug “Мемоfit” is 4.12±0.09 c.u., correspondently, that is statistically significant in relation to the group of animals, that were subjected to immobilization stress 6.23±0.03 c.u. (Р<0.05). The level of SOD at immobilization stress + combination drug “Memofit” reaches 4.16±0,09 c.u. correspondently, that is statistically significantly in relation to immobilization stress 7.13±0.89 c.u. and control 3.59±0.11 (Р<0.05). | ru_RU |
dc.language.iso | en | ru_RU |
dc.subject | neuromediatory action | ru_RU |
dc.subject | combination drug | ru_RU |
dc.subject | chronic immobilization stress | ru_RU |
dc.title | The study of neuromediatory action of the combination drug “Memofit” under chronic immobilization stress | ru_RU |
dc.type | Article | ru_RU |
Appears in Collections: | Наукові праці. Кафедра медичної та біоорганічної хімії |
Files in This Item:
File | Description | Size | Format | |
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статья мемофіт.pdf | 464,39 kB | Adobe PDF | View/Open |
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