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|Title:||The study of neuromediatory action of the combination drug “Memofit” under chronic immobilization stress|
chronic immobilization stress
|Citation:||The study of neuromediatory action of the combination drug “Memofit” under chronic immobilization stress / E. V. Savelieva, I. M. Vladimirova, O. V. Kulikova T. S. Tishakova, Ya. O. Butko // The bulletin the national academy of sciences of the republic of Kazakhstan. – 2019. – Vol. 1, № 377. – P. 6–13.|
|Abstract:||Neuromediatory action of the combination drug “Memofit” has been studied using the parameters of lipid peroxidation products and antioxidant system. POL and antioxidant system were determined by marker indicators: specifically, the level of primary oxidation products – diene conjugates and secondary products – malonic dialdehyde; anti-oxidative systems; catalase activity and superoxide dismutase. Experimental research has been performed in 18 WAG rats with approximate body weight from 210 to 230 g. Stress-modeling action has been studied on the model of neuromuscular tension during 5, 15 and 30 days. Immobilization stress was modeled by keeping rats for 5 hours in plastic cages – plastic boxes. Blood serum was used for investigation. Level of primary oxidation products – diene conjugates (DC) and secondary products – malonic dialdehyde (MDA) and state of antioxidant system has been determined by spectrophotometric method. Based on the POL level parameters, we can make a conclusion, that the tested combination drug “Memofit” decreases TBA-AP and DC parameters only on the 30-th day statistically significant in relation to immobilization stress and reaches to control. The level of catalase at immobilization stress + combination drug “Мемоfit” is 4.12±0.09 c.u., correspondently, that is statistically significant in relation to the group of animals, that were subjected to immobilization stress 6.23±0.03 c.u. (Р<0.05). The level of SOD at immobilization stress + combination drug “Memofit” reaches 4.16±0,09 c.u. correspondently, that is statistically significantly in relation to immobilization stress 7.13±0.89 c.u. and control 3.59±0.11 (Р<0.05).|
|Appears in Collections:||Наукові праці. Кафедра медичної та біоорганічної хімії|
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