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http://repo.knmu.edu.ua/handle/123456789/21630
Title: | Polymorphism of the renin-angiotensin system genes and endothelial no-synthase gene in obese patients with arterial hypertension |
Authors: | Ashcheulova, Tetyana Gerasimchuk, Nina Demydenko, Ganna Kulikova, Mariia |
Keywords: | endothelial nitric oxide synthase renin-angiotensin system gene polymorphism hypertonic disease obesity |
Issue Date: | Dec-2018 |
Citation: | Polymorphism of the renin-angiotensin system genes and endothelial no-synthase gene in obese patients with arterial hypertension / T. V. Ashcheulova, N. N. Gerasimchuk, G. V. Demydenko, M. V. Kulikova // Biopolymers and Cell. – 2018. – Vol. 34, N 5. – P. 331–349. – doi: http://dx.doi.org/10.7124/bc.000988. |
Abstract: | The review is dedicated to relationships between the blood pressure and body mass. Endothelial dysfunction and imbalance of neurohumoral systems, namely, the pathological increase in the activity of the renin-angiotensin system, in combination with obesity are the main mechanisms of the of the hypertonic disease pathogenesis. Here we discuss the research on polymorphism of the renin angiotensinic system genes and the endothelial synthase nitric oxide gene. The difficulty lies in the correct assessment of associations of alleles which have clinical signifi- cance. It is essential to determine precisely the associations of gene polymorphisms in the hypertonic disease with obesity. This provides an opportunity to identify new personified approaches to the treatment of patients with this complex pathology. |
URI: | https://repo.knmu.edu.ua/handle/123456789/21630 |
Appears in Collections: | Наукові праці. Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки |
Files in This Item:
File | Description | Size | Format | |
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BaC_#5_2018_Ashcheulova.pdf | 400,7 kB | Adobe PDF | View/Open |
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