Microscopic features of the spleen under the influence of laproxides

Abstract

Pollution of the environment and its influence on the body is a very urgent problem for medicine, as it is accompanied with increase in the incidence among the population [4,15]. A variety of environmental factors determines a wide range of morphological and functional changes in humans and animals. Diverse xenobiotics have an immunosuppressive effect and, therefore, the organism becomes responsive to viral, bacterial and parasitic diseases [11,14]. Chronic exposure to some well-absorbed but slowly eliminated xenobiotics can lead to their bioaccumulation in living organisms [2]. Exposure to environmental agents can compromise numerous immunological functions with immunotoxicological focuses on the evaluation of the potential adverse effects of xenobiotics on immune mechanisms that can lead to harmful changes in host responses such as: increased susceptibility to infectious diseases and tumorigenesis; the induction of hypersensitivity reactions; or an increased incidence of autoimmune disease [6]. One of xenobiotics type is class of polyethers belonging to the group called “Laproxides”, which are used in various sectors of the economy for the obtaining plastics, epoxy resins, lacquers, enamels, adhesives, etc. For the present research widely used polyether – tryglycidyl ether of polyoxypropylenetriol (TEPPT) [13] with molecular weight 303 (L-303) was chosen. Manufactures based on polyethers are used in machine-building, radio engineering, pharmaceutical, chemical, aviation, automotive and other branches of the national economy. The choice of this group of substances was performed due to large volumes of production, extensive contact with the population, the lack of prognostic characteristics of their potential danger for humans and warm-blooded animals, and the need to justify pathological mechanisms of structural and metabolic disorders under prolonged intake of subtoxic doses Immunotoxicology is the study of undesired modulation of the immune system by extrinsic factors. Toxicological assessments have demonstrated that the immune system is a target following exposure to a diverse group of xenobiotics including ultraviolet radiation, chemical pollutants, therapeutics, and recreational drugs [10,16]. The immune system plays a crucial role in maintaining health; however, accumulating evidence indicates that this system can be the target for immunotoxic effects caused by a variety of chemicals including the environmental pollutants [6]. The organs of the lymphoid system take participation in maintaining the constancy of homeostasis, among the first responding to exogenous influences and have the high potential to ensure the adaptation processes while the adverse impact of chemicals. According to the scientific literature, detergents have found wide enough tests on laboratory animals; a number of experimental studies demonstrated