DSpace About DSpace Software DSpace
 

Repository KhNMU >
Кафедри >
Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки >
Наукові роботи молодих вчених. Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки >

Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/20463

Название: Carbohydrate and lipid disorders and adipokines levels in relation to body mass index in hypertensive patients
Другие названия: Trastorno del metabolismo de carbohidratos y lípidos y los niveles de adipoquinas en relación con el índice de masa corporal en pacientes con hipertensión
Авторы: Ashcheulova, Tetiana
Demydenko, Ganna
Ambrosova, Tetiana
Kysylenko, Kateryna
Gerasimchuk, Nina
Kochubiei, Oksana
Ключевые слова: Adipokine
hypertension
interleukin-22
nutritional status
obesity
Issue Date: 2018
Издатель: Revista Mexicana de Cardiología
Библиографическое описание: Carbohydrate and lipid disorders and adipokines levels in relation to body mass index in hypertensive patients / T. Ashcheulova, G. Demydenko, T. Ambrosova, K. Kysylenko, N. Gerasimchuk, O. Kochubiei // Revista Mexicana de Cardiología. – 2018. – Vol. 29 (2). – P. 74–82.
Аннотация: Obesity is considered as a valid risk factor for cardiovascular disease, due to the fact that the risk of morbidity and mortality from various causes in obese people is signifi cantly higher. Exact mechanisms of metabolic disorders in hypertension with obesity is still discussible. The aim of the study – to determine the peculiarities of carbohydrate, lipid metabolism changes and activity of adipokines and interleukin-22, in patients with hypertension according to nutritional status. Methods: 80 patients (37 males and 43 females) with essential hypertension (EH) of average age 60.17 years were examined. Carbohydrate, lipid profi les, apolipoprotein B (apo B), tumor necrosis factor-α (TNF-α), plasminogen activator inhibitor-1 (PAI-1), adiponectin, interleukin-22 (IL-22) were estimated. Results: In patients with EH and obesity was found carbohydrates metabolism abnormalities, that was manifested as hyperinsulinemia, glucose and HbA1c levels elevation and insulin resistance (according to HOMA index). Lipid metabolism disorders were observed as valid increasing of triglycerides and apo B. Body mass index elevation was associated with progressive increasing of TNF-α and PAI-1 concentration with reducing of adiponectin level in the patients with EH. Positive relationships between TNF- and HbA1c, apo B; PAI-1 with glucose levels: negative correlation adiponectin with body mass and waist to hip ratio were detected in the patients with obesity associated (BMI ≥ 30 kg/m2) EH. Positive signifi cant correlations between apo B and insulin levels, HOMA index, and TNF-α concentration were defi ned. IL-22 in overweigh and obese patients was signifi cantly higher, correlates negatively with HDL-C. Conclusion: In patients with EH and obesity the adipokine dysfunction was revealed, that correlates with carbohydrate and lipid parameters that indicate increased proinfl ammatory and prothrombogenic processes.
URI: http://repo.knmu.edu.ua/handle/123456789/20463
Appears in Collections:Наукові роботи молодих вчених. Кафедра пропедевтики внутрішньої медицини № 1, основ біоетики та біобезпеки

Files in This Item:

File Description SizeFormat
h182a.pdf276,67 kBAdobe PDFView/Open


This item is protected by original copyright

View Statistics

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

 

Valid XHTML 1.0! DSpace Software Copyright © 2002-2010  Duraspace - Feedback