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Название: Development of composition and technology of combination drug with neurally mediated action «Memofit»
Авторы: Savelieva, Olena
Vladymyrova, Inna
Тishakova, Tatyana
Levashova, Olga
Ключевые слова: technology
solid formulations
capsules
plant extracts
diseases of the nervous system
Дата публикации: 2017
Библиографическое описание: Development of composition and technology of combination drug with neurally mediated action «Memofit» / O. Savelieva, I. Vladymyrova, Т. Тishakova, O. Levashova // ScienceRise: Pharmaceutical Science. – 2017. – № 6 (10). – Р. 38–44.
Аннотация: Aim. The aim of this work is to develop composition of combination drug in the form of hard-gelatin capsules «Memofit», determine technological and microbiological parameters of intermediate products and ready medicinal product and develop of manufacturing process for capsules «Memofit». Methods of the research. Investigations presented in the article were performed in accordance with the procedures described by the State Pharmacopoeia of Ukraine (SPh Ukraine). The results of the research. Necessity of the development of dietary supplement to provide special dietary properties for the purpose of regulation of functions and systems of the organism within the physiologically normal states under the nervous system dysfunction was substantiated. Results of the study of pharmaco-technological and microbiological parameters of dry extracts that are included as a compound of hard-gelatin capsules «Memofit» were presented. Optimal technological parameters for manufacturing process of capsules «Memofit» were proposed. Results of mass balance for a batch of capsules «Memofit» proved rationality of selected manufacturing process were given. Technology of manufacturing process of capsules «Memofit» was introduced into the production on the TOV “DZ “GNCLS”. Conclusions. Possibility of the development of solid formulations in the form of capsules was established based on the obtained experimental findings of the determination of pharmaco-technological and microbiological parameters of dry extracts. It was shown that capsules «Memofit» are used in dietary food ration as additional source of biologically active substances for promoting normalization of brain function and sleep, improvement of attentiveness. This preparation has general tonic properties and improves mental and physical efficiency. Manufacturing process and process flow chart for this medication was substantiated
URI: http://repo.knmu.edu.ua/handle/123456789/19026
Располагается в коллекциях:Наукові праці. Кафедра медичної та біоорганічної хімії

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