Calcium metabolism changes as a formation mechanism of diabetic foot in geriatric patients

Abstract

Identified differences of calcium metabolism indicate signs of calcium malabsorption in DM patients and the processes of bone resorption intensification. This allows to conclude that calcium metabolism status (in particular, the severity of bone resorption) has significance at the development of diabetic hard tissue foot lesions as well as diabetic neuropathies and angiopathies. Insulin has a significant anabolic effect. It is known that a insulin production decreasing leads to the bone mineralization decreasing, reducing of the calcium blood serum level, increasing of the calcium urine secretion. The bone tissue trophics is broken – this is a result of the carbohydrate metabolism changes at cells and vascular lesions during insulin deficiency. Calcium metabolism and bone resorption changes defined at the study point to the necessity of the calcium drugs including to the complex therapy of DM.