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Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/15094

Название: Significance of the body weight in endothelial dysfunction changes and systemic inflammation progression in coronary artery disease patients
Авторы: Shaposhnikova, Yuliya Nikolaevna
Ilchenko, Irina Anatolievna
Bobronnikova, Lesya Romanovna
Ключевые слова: endothelial dysfunction
systemic inflammation
coronary artery disease
endothelium-dependent vasodilatation
endothelium-independent vasodilatation
Issue Date: 2016
Библиографическое описание: Shaposhnikova Y. Significance of the body weight in endothelial dysfunction changes and systemic inflammation progression in coronary artery disease patients / Y. N. Shaposhnikova, I. A. Ilchenko, L. R. Bobronnikova // Anitschkow Days Symposium of the International Atherosclerosis Society, St. Petersburg, Russia, June 2–4, 2016 : Book of Abstracts. – [S. l.], 2016. – P. 245.
Аннотация: n patients with stable exertional angina II functional class with increasing BMI occurs inhibition of endothelial function and activation of systemic inflammation, manifested by decrease EDVD and ENVD and rising CRP, which adversely affects on the course of coronary artery disease and induces the development of vascular complications. This risk appears to stem from multiple abnormalities in adipose tissue function leading to a chronic inflammatory state and to dysregulation of the endocrine and paracrine actions of adipocyte-derived factors. These, in turn, disrupt vascular homeostasis by causing an imbalance between the NO pathway and the endothelin 1 system, with impaired insulin-stimulated endothelium-dependent vasodilation.
URI: http://repo.knmu.edu.ua/handle/123456789/15094
Appears in Collections:Наукові праці. Кафедра клінічної фармакології та внутрішньої медицини

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