Structural functional parameters of the heart in patients with coronary heart disease with concomitant obesity depending on genotypes of gene of tumor necrosis factor-α (G-308A)

Abstract

The article deals with influence of different genotypes of gene of tumor necrosis factor-α on changes of structure and function of the myocardium in patients with coronary heart disease with concomitant obesity by means of examination of 222 patients. Conclusions. In patients with coronary heart disease (CHD) and obesity with genotype A/A of TNF-α gene (G-308A) more significant disorders in structure and function of the myocardium are observed, that is increased dimensions of the left ventricle, its mass associated with reduced contraction ability, which results in unfavorable left ventricle remodeling and development of diastolic dysfunction of the left ventricle.