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Title: Causes and physiological mechanisms of myasthenia gravis
Authors: Donthula, S.K.
Hloba, N.S.
Karmazina, I.S.
Keywords: Lambert-Eaton syndrome
Myasthenia gravis
Muscle specific kinases
Antibodies of IgG type
Issue Date: 18-May-2016
Publisher: Харківський Національний Медичний Університет
Citation: Donthula S. K. Causes and physiological mechanisms of myasthenia gravis / S. K. Donthula, N. S. Hloba, I. S. Karmazina // Фізіологія медицині, фармації та педагогіці: «Актуальні проблеми та сучасні досягнення» : тези доповідей ІII Всеукраїнської студентської наукової конференції з фізіології з міжнародною участю, Харків, 18 травня 2016 р. – Харків, 2016. – С. 7–8.
Abstract: Disorders caused by impaired function of neuromuscular junction are seen fairly often, and their mechanisms still remain unclear. All disorders of this group are considered painless, because in the patients the painless muscle fatigue is observed. The objective of this work was to analyze the existing data and to determine the possible reasons and physiological mechanisms of one of those disorders – myasthenia gravis.
Description: Myasthenia gravis is the autoimmune impairment of neuromuscular junction with 2 possible mechanisms – blockage of nicotinic cholinergic receptors and blockage of MuSK proteins. Based on those mechanisms, modern treatment of MG includes the correction of relative deficiency of acetylcholine, suppression of autoimmune process, thymus x-ray therapy and removal, etc. However, the efficiency of treatment is relative, and the response to any form of treatment is difficult to assess because the severity of symptoms fluctuates. All these facts prove the necessity of future thorough study of myasthenia gravis and its mechanisms.
Appears in Collections:Наукові роботи молодих вчених. Кафедра фізіології

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