Modern practice of internal medicine with emergency conditions. Management of patients with weight loss

Abstract

There are a number of different disease wich conducting with weight loss. Such as systemic lupus erythematosus (SLE), dermatomyositis, systemic sclerosis, inflammatory bowel disease (Chron's disease, ulcer colitis, irritable bowel disease, celiac disease) and cancer. All of the disease have different mechanic of pathophysiology accoding to the etiology of their. In addition to psychosocial distress, anorexia/cachexia limits therapeutic options. Weight loss correlates with treatment toxicity and poor tumor response. Recent studies suggest that inflammatory cytokines associated with primary anorexia/cachexia interfere with hepatic medication metabolism and may even block chemotherapeutic anti tumor effects directly or through induction of acute-phase proteins.