Please use this identifier to cite or link to this item: http://repo.knmu.edu.ua/handle/123456789/12614
Title: Age-dependent peculiarities modulation of activity of aldehyde scavenger enzymes in mitochondria of rat thigh muscle during stress
Authors: Davydov, Vadim Vyacheslavovich
Grabovetskaya, Evgeniya Romanovna
Hamdallah, Amjad
Keywords: aldehydes
mitochondria
muscle
immobilization
stress
aging
Issue Date: 2016
Citation: Davydov V. V. Age-dependent peculiarities modulation of activity of aldehyde scavenger enzymes in mitochondria of rat thigh muscle during stress / V. V. Davydov, E. R. Grabovetskaya, A. Hamdallah // Frontiers in Biology. – 2016. – Vol. 11, issue 1. – P. 28–31.
Abstract: The purpose of this study was a comparative investigation of activity of aldehyde scavenger enzymes in mitochondrial fraction of a thigh muscle in intact and immobilized rats of different ages. It has been shown that 12-month-old (adult) rats have high basal levels of aldehyde dehydrogenase, aldehyde reductase and glutathione transferase activity in mitochondrial fraction of thigh muscle. Aldehyde dehydrogenase activity increases during immobilization stress in adult rats. This change promote to enhance the effectiveness of utilization of carbonyl products of free radical oxidation in mitochondria of skeletal muscle of 12-month-old rats during stress. Immobilization of old and pubertal rats is accompanied by metabolic preconditions leading to accumulation of endogenous aldehydes in mitochondria, and, as a result, to the injury of muscular fibers and intensification of sarcopenia manifestations.
URI: http://repo.knmu.edu.ua/handle/123456789/12614
Appears in Collections:Наукові праці. Кафедра медичної та біоорганічної хімії

Files in This Item:
File Description SizeFormat 
Статья age-dependent.docx32,93 kBMicrosoft Word XMLView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.